To assess the 81 patients with mild infections, the team took magnetic resonance imaging (MRI) scans of their brains and compared these with scans from 145 volunteers with no history of COVID-19. In other words, brain changes seen in mild infection may not be driven by the same mechanisms as those seen in tissue from people who died of COVID-19, she told Live Science in an email. Maria Nagel, a professor of neurology and ophthalmology at the University of Colorado School of Medicine, who was not involved in the study.
Given the stark differences between each arm of the study, "I think it is difficult to compare the mild disease portion of the study to the severe disease cohort," said Dr. The new study pulled data from three sources: cells in lab dishes, brain tissue from deceased patients and brain scans from living patients who had recovered from mild COVID-19 infections. The new study may add astrocytes to the long list of cells that SARS-CoV-2 attacks, but many questions about COVID-19 and the brain remain unanswered, the authors said. Other studies have found that the coronavirus can also directly infect neurons, although the virus's exact route into the brain is still under investigation, Live Science previously reported. "It doesn't get there every time, but it can get there." "The main message in the paper is that the virus is able to get there, ," said study author Daniel Martins-de-Souza, an associate professor and the head of proteomics in the Department of Biochemistry at the University of Campinas in Brazil.
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